Los Angeles — New research presented today at the American Psychiatric Association’s Annual Meeting shows that GLP-1 receptor agonists may be able to help cigarette smokers reduce weight gain while they are quitting.

A team led by Debora Xavier, M.D., conducted a systematic review and meta-analysis to determine how abstinence from cigarettes and post-cessation weight gain were affected by the presence of Glucagon-like peptide-1 receptor agonists (GLP-1RA) agents. Traditionally used to treat type 2 diabetes and obesity, GLP-1RA agents may play a role in the pathophysiology of addiction.

A literature review surfaced three randomized controlled trials that met the inclusion criteria, representing 410 patients and 207 GLP-1RA users. For those who abstained from cigarettes, GLP-1RAs significantly reduced post-cessation weight gain; GLP-1RA users lost weight while the control groups gained weight. The implications of the study are encouraging, given that cigarette smoking is the leading cause of preventable disease and death in the U.S.

“GLP-1 receptor agonists may offer a promising path to help smokers quit by addressing one of their biggest concerns: weight gain,” said Dr. Xavier. “Their neuromodulation effects can potentially reduce the rewarding effects of both nicotine and food.”

Researchers also note that the long-term efficacy of GLP-1s on quitting smoking is relatively modest, particularly due to the cravings and weight gain that may occur after cessation.

The study authors included Debora Xavier, M.D., Gabriel Alves, Isabela Borja de Oliveira, Murilo Luis Geremias, and Marilia Brasil Xavier, M.D., Ph.D.

American Psychiatric Association

The American Psychiatric Association, founded in 1844, is the oldest medical association in the country. The APA is also the largest psychiatric association in the world with more than 39,200 physician members specializing in the diagnosis, treatment, prevention, and research of mental illnesses. APA’s vision is to ensure access to quality psychiatric diagnosis and treatment. For more information, please visit www.psychiatry.org.